USP14: STRUCTURE, FUNCTION, AND TARGET INHIBITION

USP14: Structure, Function, and Target Inhibition

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation.USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome.Incre

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Challenges and Future Perspectives for Additively Manufactured Polylactic Acid Using Fused Filament Fabrication in Dentistry

Additive manufacturing (AM), which is also called rapid prototyping/3D printing/layered manufacturing, can be considered as a rapid conversion between digital and physical models.One of the most used materials in AM is polylactic acid (PLA), which has advantageous material properties such as biocompatibility, biodegradability, and nontoxicity.For m

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